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HOMERESEARCHPUBLICATIONSLAB MEMBERSCOURSES/LINKSPOSITIONSCONTACT
SELECTED PUBLICATIONS:

OUR PAPERS ON PUBMED
You can download our papers at ResearchGate

SELECTED PAPERS 
 

o  Musilova K, Devan J, Cerna K, Seda V, Pavlasova G, Sharma S, Oppelt J, Pytlik R, Prochazka V, Prouzova Z, Trbusek M, Zlamalikova L, Liskova K, Kruzova L, Jarosova M, Mareckova A, Kornauth C, Simonitsch-Klupp I, Schiefer AI, Merkel O, Mocikova H, Burda P, Machova Polakova K, Kren L, Mayer J, Zent CS, Trneny M, Evans AG, Janikova A, Mraz M.miR-150 downregulation contributes to the high-grade transformation of follicular lymphoma by upregulating FOXP1 levels. Blood. 2018 Sep 13 (epub). Impact factor: 15,1  

o  Pavlasova G, Borsky M, Svobodova V, Oppelt J, Cerna K, Novotna J, Seda V, Fojtova M, Fajkus J, Brychtova Y, Doubek M, Pospisilova S, Mayer J, Mraz M. Rituximab primarily targets an intra-clonal BCR signaling proficient CLL subpopulation characterized by high CD20 levels. Leukemia. 2018 Jul 20 (epub). Impact factor: 10 

o Cerna K, Oppelt J, Chochola V, Musilova K, Seda V, Pavlasova G, Radova L, Arigoni M, Calogero RA, Benes V, Trbusek M, Brychtova Y, Doubek M, Mayer J, Pospisilova S, Mraz M. MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells. Leukemia. 2018 Aug 15. (epub). Impact factor: 10 

o Devan J, Janikova A, Mraz M. New concepts in follicular lymphoma biology: From BCL2 to epigenetic regulators and non-coding RNAs (review). Seminars in Oncology. 2018 Oct 22. (epub). Impact factor: 5 

Mraz M, Pospisilova S. Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement. British Journal of Haematology. 2019 (epub). Impact factor: 5,1 

o Cerna K, Mraz M. p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1 (Editorial). Oncotarget. 2018 (in press). Impact factor: 5,2 

o  Boudny M, Zemanova J, Khirsariya P, Borsky M, Verner J, Cerna J, Oltova A, Seda V, Mraz M, Jaros J, Jaskova Z, Spunarova M, Brychtova Y, Soucek K, Drapela S, Kasparkova M, Mayer J, Paruch K, Trbusek M. Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. Haematologica. 2019 Apr 11 (epub). Impact factor: 9.1 

o  Pavlasova G, Borsky M, Seda V, Cerna K, Osickova J, Doubek M, Mayer J, Calogero R, Trbusek M, Pospisilova S, Davids MS, Kipps TJ, Brown JR, Mraz M. Ibrutinib inhibits CD20 up-regulation on CLL B cells mediated by the CXCR4/SDF-1 axis. Blood. 2016 Aug 1 (epub).Impact factor: 12 

o  Musilova K, Mraz M. MicroRNAs in B cell lymphomas: How a complex biology gets more complex. Leukemia.2015 May;29(5):1004-17.Impact factor: 9,4 

Mraz M, Chen L, Rassenti LZ, Ghia EM, Li H, Jepsen K, Smith EN, Messer K, Frazer KA, Kipps TJ. MicroRNA-150 contributes to the proficiency of B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1 genes. Blood. 2014 Jul 3;124(1):84-95. Impact factor: 9,8 

o  Cui B, Chen L, Zhang S, Mraz M, Fecteau JF, Yu J, Ghia EM, Zhang L, Bao L, Rassenti LZ, Messer K, Calin GA, Croce CM, Kipps TJ. MicroRNA-155 Influences B-cell Receptor Signaling And Associates With Aggressive Disease In Chronic Lymphocytic Leukemia. Blood. 2014 Jul 24;124(4):546-54.Impact factor: 9,8 

o  Seda V, Mraz M. B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells. Eur J Haematol. 2015 Mar;94(3):193-205.Impact factor: 2,4 

Mraz M, Pospisilova S. MicroRNAs in chronic lymphocytic leukemia: from causality to associations and back. Expert Rev Hematol. 2012 Dec;5(6):579-81. Editorial 

Mraz M, Kipps T. MicroRNAs And B Cell Receptor Signaling in Chronic Lymphocytic Leukemia. Leukemia and Lymphoma 2013 Aug;54(8):1836-9. Impact factor: 2,6 

o Dolezalova D, Mraz M*, Barta T, Plevova K, Vinarsky V, Holubcova Z, Jaros J, Dvorak P, Pospisilova S, Hampl A. MicroRNAs Regulate p21(Waf1/Cip1) Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells. Stem Cells. 2012;30(7):1362-72.; shared first author and corresponding author, Impact factor: 7,781 

Mraz M*, Dolezalova D, Plevova K, Stano Kozubik K, Mayerova V, Cerna K, Musilova K, Tichy B, Pavlova S, Borsky M, Verner J, Doubek M, Brychtova Y, Trbusek M, Hampl A, Mayer J, Pospisilova S.MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. Blood. 2012 Mar 1;119(9):2110-3.first and corresponding author; Impact factor: 10,56 

Mraz M, Zent CS, Church AK, Jelinek DF, Wu X, Pospisilova S, Ansell SM, Novak AJ, Kay NE, Witzig TE, Nowakowski GS. Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin α-4-β-1 (VLA-4) with natalizumab can overcome this resistance. Br J Haematol. 2011;155(1):53-64.; Impact factor: 4,9419 

o Mraz M,Malinova K, Kotaskova J, Pavlova S, Tichy B, Malcikova J, Stano Kozubik K, Smardova J, Brychtova Y, Doubek M, Trbusek M, Mayer J, Pospisilova S. miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia. 2009;23(6):1159-63.; Impact factor: 8.966 58 

o Vargova K, Curik N, Burda P, Basova P, Kulvait V, Pospisil V, Savvulidi F, Kokavec J, Necas E, Berkova A, Obrtlikova P, Karban J, Mraz M, Pospisilova S, Mayer J, Trneny M, Zavadil J, Stopka T. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. 2011;117(14):3816-25.; Impact factor: 10,56 

o Trbusek M, Smardova J, Malcikova J, Sebejova L, Dobes P, Svitakova M, Vranova V, Mraz M, Skuhrova Francova H, Doubek M, Brychtova Y, Kuglik P, Pospisilova S, Mayer J. Missense Mutations Located in Structural p53 DNA-binding Motifs Are Associated with Extremely Poor Survival in Chronic Lymphocytic Leukemia. Journal of Clinical Oncology. 2011;29(19):2703-8.; Impact factor: 18,9 

o Dolezalova D, Mraz M, Hampl A. miRNA in Embryonic Stem Cells. In MICRORNA IN REGENERATIVE MEDICINE 2015 (Elsevier Inc.) (chapter in book)